Abstract: Application of Stereotactic Needle Localized Biopsy Guided by Digital Mammography inNon-palpable Breast LesionsXiaolei XUE, Zhaoxiang YE, Yumei ZHAO, Chun QING, Jie LIU, Peifang LIUCorrespondence to: Zhaoxiang YE, E-mail: yezhaoxiang@163.comDepartment of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Preventionand Therapy of Education Ministry, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaAbstract Objective: To evaluate the value of stereotactic needle localized biopsy guided by digital mammography in non-palpa-ble breast lesions. Methods: Retrospective analysis was conducted in 40 cases of non-palpable breast lesions with malignant signs suchas clusters of calcification, poorly-demarcated nodules or regional structural irregularities in the digital mammography. After computer-ized stereotactic puncture of the lesions was done, a guide wire was indwelled in the suspected spot. With the guidance of the wire, sur-gical resection of the suspected tissue was performed. In order to confirm whether the lesions were completely removed, the patients un-derwent mammography after surgical resection. Pathological diagnosis of the removed tissue was obtained. Results: Digital mammogra-phy showed 41 lesions in these 40 patients and 41 wires were indwelled to guide the surgical biopsy. Thirty-three cases had cluster or ir-regular calcification ( 80.5% ), one case had partial structural disorder ( 2.4% ) and 7 cases had masses ( 17.1% ). Pathological examina-tion showed breast carcinoma in 16 cases ( 39.0% ), including 13 cases of intraductal carcinoma ( 31.7% ) and 3 cases of invasive duc-tal carcinoma ( 7.3% ); benign lesions in 25 cases ( 61.0% ), including 6 cases of fibroadenoma ( 14.6% ), 2 cases of intraductal papil-lary carcinoma ( 4.9% ), and 17 cases of hyperplasia ( 41.5% ). The detection rate of breast carcinoma was 39.0%. The lesions were100% removed by wire location guided resection. Conclusion: Surgical biopsy with the guidance of indwelling wire placed through ste-reotactic puncture guided by digital mammography is helpful in correctly localizing and removing small latent breast lesions. It cansolve the surgical difficulties due to blind resection, and can help to confirm the diagnosis of the lesions, indicating its significant valuein detecting early breast carcinoma.Keywords Breast disease; Mammography; Biopsy; Stereotactic technique